CAR-T Cancer Therapy: Hope For Patients and Healthcare Industry Expansion Driver

CAR-T Cancer Therapy: Hope For Patients and Healthcare Industry Expansion Driver

In March, the Ministry of Health, Labour and Welfare approved Bristol Myers Squibb’s Breyanzi CAR-T cell therapy for certain types of lymphoma cancers, making it the third such treatment to have received approval in Japan. The huge domestic healthcare market, totalling approximately 43.4 trillion yen ($398 billion dollars) in FY2018, is undergoing some significant shifts.

Shortly after Shinzo Abe became prime minister for the second time in late 2012, he announced plans to position Japan as a global leader in regenerative medicine, committed to investing 110 billion yen annually to related research, and to deregulation. This followed the spotlight being shone on regenerative medicine by the joint award of the 2012 Nobel Prize in Physiology or Medicine to Kyoto University’s Shinya Yamanaka for his ground-breaking research on iPS cells.   

2014 saw the Abe administration follow through on its promise of deregulation with two new laws: the Act on the Safety of Regenerative Medicine and the Pharmaceutical and Medical Devices Act. These allowed for the fast-tracking of cellular therapies to an extent that surprised even many in the industry, and has led to the creation of thousands of new potential treatments.

Obtaining Critical Government Approval  

Japan has made huge strides in regenerative medicine in the years since the Abe government launched its initiatives, including the work of Hiroshima University’s Professor Mitsuo Ochi, who has helped revolutionise knee surgery with his cutting-edge techniques.

However, one of the most promising treatments – CAR-T cell (T cell) therapy – has meanwhile emerged from the US.  Extracted from a patient’s blood, the chimeric antigen receptor (CAR) T cells are modified to attack the cancer and then injected back into their body.

Novartis’ Kymriah treatment secured reimbursement from national health insurance in May 2019, followed by Gilead’s Yescarta (licensed by Daiichi Sankyo) approval in January this year. With costs for each treatment running to tens of millions of yen, coming under the national health insurance system was crucial.   

The latest approval should further boost the availability of CAR-T therapy and demand for professionals in the field.

Domestic Scientific Breakthroughs In The Field

The cost of CAR-T treatments could be on the verge of being drastically reduced if work on new methods of creating cells at Kyoto University’s Center for iPS Cell Research and Application (CiRA) comes to fruition.

In January, CiRA Professor Shin Kaneko reported that his lab has been able to produce T cells from iPS cells for cancer immunotherapy on a large scale. This eliminates the need to remove cells from a patient’s blood and allows for the production of huge numbers of ‘stock cells’ which can be used in CAR-T.  

“The advantage of combining CAR-T therapy and iPS cells is that we can make many T cells from the iPS cell stock to attack any type of cancer,” explained Kaneko when announcing the findings. “The stock removes the need to take cells from the patient, which requires time. Instead, our goal is to make an ‘off-the-shelf’ T cell product from iPS cells that is no different than getting a blood transfusion in the hospital.”

Kaneko and his team have also devised a way to modify iPS cells so that they are not attacked by a patient’s immune system.

“It’s possible it could be applied not just with T cells, but in transplantation medicine using other cells derived from iPS cells,” Kaneko told the Mainichi Shimbun in May, shortly after the research was published in the UK science journal Nature.  

Research into CAR-T therapies for other forms of cancer is also ongoing, setting the stage for further expansion in the future, something also likely to be seen across a range of regenerative medicine areas.

The Need For Talent 

The rapid expansion of this promising field is leading to companies scrambling to find talent.  “This is a very active area within healthcare at the moment and companies are aggressively looking to expand their capabilities in the field,” says Head of Healthcare at Slate Consulting, Yonoshin Takagi. There is very strong demand for Car-T professionals in a wide range of expertise such as QA, Marketing ,Production and Medical Affairs. 

Research into CAR-T therapies for other forms of cancer is also ongoing, setting the stage for further expansion in the future, something also likely to be seen across a range of regenerative medicine areas.

By: Gavin Blair

To find out more about hot roles in healthcare and elsewhere please contact us at +81-3-5962-5888 or email us at

106 Responses

  1. Millard says:

    Touche. Great arguments. Keep up the great work.

  2. Sol says:

    I visited many sites however the audio feature for audio songs present at this
    website is actually wonderful.

  3. Corina says:

    Hey would you mind sharing which blog platform you’re working with?
    I’m planning to start my own blog soon but I’m having a difficult time deciding between BlogEngine/Wordpress/B2evolution and Drupal.
    The reason I ask is because your design and style seems different
    then most blogs and I’m looking for something unique.

    P.S Apologies for being off-topic but I had to ask!

  4. Remarkable! Its genuinely awesome piece of writing,
    I have got much clear idea concerning from this article.

  5. Hello there, You have done a fantastic job.
    I will definitely digg it and personally recommend to my friends.
    I’m confident they’ll be benefited from this site.

  6. Wһy people still use to reаd news papers when in thos technological worpd everyhing іis available on web?

  7. xbets ag says:

    Great beat ! I would like to apprentice even as you amend
    your web site, how could i subscribe for a blog web site?
    The account helped me a acceptable deal. I have been a
    little bit familiar of this your broadcast provided bright clear idea

  8. I’m impressed, I must say. Seldom do I come across a blog that’s both equally educative and amusing, and let me tell you, you have
    hit the nail on the head. The problem is an issue that too few folks are speaking intelligently about.
    I’m very happy I came across this during my search for something regarding this.

  9. Hello, I enjoy reading all of your post. I wanted to write a little
    comment to support you.

  10. Alejandro says:

    I am sure this post has touched all the internet users, its really really pleasant
    paragraph on building up new website.

  11. the spread says:

    Hi! I just wish to give you a huge thumbs up for your excellent info you have got
    here on this post. I will be returning to your site for more soon.

  12. Jessie says:

    Simply desire to say your article is as surprising. The clearness in your post is just spectacular and i could assume you are an expert on this subject.
    Well with your permission allow me to grab your feed to keep updated with forthcoming post.
    Thanks a million and please continue the enjoyable work.

  13. Jann says:

    Pretty! This was an extremely wonderful article. Thanks for supplying this info.

  14. Its like you learn my thoughts! You appear to know a lot approximately this, like you wrote the book in it or something.
    I believe that you simply could do with some p.c.
    to pressure the message house a little bit, however instead of that, this is fantastic blog.
    A great read. I will certainly be back.

  15. Connie says:

    I have been surfing online more than 3 hours as of late, yet I never discovered any
    fascinating article like yours. It is beautiful value
    enough for me. In my view, if all web owners and bloggers made excellent
    content material as you probably did, the net will probably be a lot more useful
    than ever before.

  16. It’s awesome to visit this web page and reading the views of all mates
    on the topic of this article, while I am also
    zealous of getting know-how.

  17. You really make it seem really easy together with your presentation but I
    to find this topic to be really one thing which I believe I might by no means understand.
    It kind of feels too complicated and very extensive for me.
    I’m having a look forward in your subsequent post, I will attempt to get the hold of it!

  18. freespin says:

    Heya i’m for the first time here. I found this board and I find It truly
    useful & it helped me out a lot. I hope to give something back
    and help others like you helped me.

  19. you’re truly a good webmaster. The web site loading velocity is amazing.
    It sort of feels that you’re doing any distinctive trick.
    Moreover, The contents are masterwork. you have done a fantastic task in this topic!

  20. ncaa line says:

    Hello There. I found your blog using msn. This is a really
    well written article. I will make sure to bookmark it
    and come back to read more of your useful information.
    Thanks for the post. I will definitely return.

  21. Excellent pieces. Keep posting such kind of info on your page.
    Im really impressed by it.
    Hey there, You’ve performed a fantastic job. I will definitely digg it and personally
    suggest to my friends. I am confident they will be benefited from this website.

  22. Anderson says:

    Attractive section of content. I just stumbled upon your website and in accession capital to assert that I get actually enjoyed account your blog posts.
    Any way I’ll be subscribing to your feeds and even I achievement you access consistently rapidly.

  23. Howdy I am so thrilled I found your website, I really found you by accident,
    while I was browsing on Bing for something else, Anyways I am here now and
    would just like to say cheers for a marvelous post and
    a all round enjoyable blog (I also love the theme/design), I don’t
    have time to read through it all at the minute but I have saved it and also included your RSS feeds, so when I have time I
    will be back to read more, Please do keep up the great work.

  24. Very nice article. I certainly appreciate this site.

  25. Spot on with this write-up, I really think this site needs a great deal more attention.
    I’ll probably be back again to read through more, thanks for the advice!

  26. Danilo says:

    Hi there! This blog post couldn’t be written any better!
    Looking at this article reminds me of my previous roommate!
    He constantly kept preaching about this. I most certainly
    will forward this information to him. Fairly certain he will have a great read.
    Thanks for sharing!

  27. xnxx says:

    It’s nearly impossible to find experienced people for this topic, however, you seem like you know what you’re talking about!


  28. x bet says:

    Hello! I know this is kinda off topic however , I’d figured I’d ask.
    Would you be interested in trading links or maybe guest authoring a blog article or vice-versa?
    My website covers a lot of the same topics as yours and I think we
    could greatly benefit from each other. If you happen to be interested feel free to shoot me an e-mail.
    I look forward to hearing from you! Superb blog by
    the way!

  29. Pleaѕe let me know iff you’re lߋoking for a writer for your site.
    Yоu have some really great articles and Ι feel I woulԁ be a goodd asset.
    If you ever want to taкe ѕomne of the liad off, Ι’d love
    to write some articles for your blog in exchange for a link back to mine.
    Please shoot mee an email if interested. Kudos!

  30. Ebony says:

    Howdy! I know this is somewhat off topic but I was wondering
    if you knew where I could locate a captcha plugin for my comment
    form? I’m using the same blog platform as yours and I’m having problems finding
    one? Thanks a lot!

  31. Heya i am for the primary time here. I came across this board and
    I find It really helpful & it helped me out much.

    I hope to offer something again and aid others such as you aided me.

  32. Heya i am for the first time here. I came across this board and I find It truly useful
    & it helped me out a lot. I hope to give something back and aid others like you helped me.

  33. Actually when someone doesn’t know afterward its up to other viewers that they will help, so here it
    takes place.

  34. xnxx says:

    Appreciating the time and effort you put into your site and detailed information you present.
    It’s awesome to come across a blog every once in a
    while that isn’t the same unwanted rehashed information. Fantastic read!
    I’ve bookmarked your site and I’m adding your RSS feeds to my
    Google account.

  35. xnxx says:

    Wonderful post! We will be linking to this particularly great article on our website.
    Keep up the good writing.

  36. xnxx says:

    I’m extremely impressed along with your writing abilities as neatly as with the layout for your weblog.
    Is that this a paid topic or did you modify it yourself?

    Either way keep up the excellent high quality writing, it is rare to see a nice weblog
    like this one today..

  37. Margareta says:

    Good post but I was wanting to know if you could write a litte more on this topic?
    I’d be very grateful if you could elaborate a little bit
    further. Thank you!

  38. It’s amazing to pay a visit this website and reading the views of all friends on the topic of this post, while I am
    also zealous of getting familiarity.

  39. It’s really a great and useful piece of info. I am satisfied that
    you shared this useful info with us. Please keep us informed like this.
    Thanks for sharing.

  40. Stromectol says:

    Composition Du Clomid

  41. manhwaland says:

    Fantastic article.Thanks Again. Really Great.

  42. I was recommended this blog by my cousin. I am not
    sure whether this post is written by him as no one else know such detailed about my problem.
    You’re wonderful! Thanks!

  43. This website definitely has all the info I needed concerning
    this subject and didn’t know who to ask.

  44. Cialis says:

    Cialis Maux De Ventre

  45. Kimhig says:

    [url=]buy cialis wholesale[/url]

  46. I’ve been exploring for a bit for any high quality articles or
    weblog posts in this sort of area . Exploring in Yahoo
    I eventually stumbled upon this web site. Studying this info So i’m happy to
    express that I have an incredibly just right uncanny feeling I came upon exactly what I needed.

    I such a lot certainly will make sure to
    do not fail to remember this web site and give it a look regularly.

  47. Joehig says:

    [url=]sildenafil 1 pill[/url]

  48. Hello! This is kind of off topic but I need some advice from an established blog.
    Is it hard to set up your own blog? I’m not very techincal but I can figure things out
    pretty quick. I’m thinking about making my own but
    I’m not sure where to begin. Do you have any tips or suggestions?

  49. Carlhig says:

    [url=]ivermectin 3 mg dose[/url]

  50. Nickhig says:

    [url=]can you buy generic cialis in canada[/url]

  51. Paulhig says:

    [url=]generic levitra in us[/url]

  52. Maryhig says:

    [url=]viagra price in india online[/url]

  53. Ashhig says:

    [url=]canadian viagra pharmacy[/url] [url=]ivermectin 8000 mcg[/url] [url=]lasix 500 mg price[/url]

  54. Yonhig says:

    [url=]viagra prescription cost uk[/url] [url=]finasteride online usa[/url] [url=]viagra cheapest pharmacy[/url] [url=]metformin 1000 mg for sale[/url] [url=]fildena 150[/url] [url=]tretinoin cream canada pharmacy[/url] [url=]purchase cialis 20 mg[/url]

  55. Amyhig says:

    [url=]stromectol xl[/url]

  56. Miahig says:

    [url=]stromectol buy uk[/url]

  57. Jimhig says:

    [url=]order cheap viagra online[/url]

  58. Teohig says:

    [url=]where can you buy modafinil over the counter[/url] [url=]sildenafil purchase canada[/url] [url=]sildenafil 20 mg brand name[/url] [url=]pharmacy tretinoin[/url] [url=]ivermectin pills[/url] [url=]where to get viagra no prescription[/url] [url=]how to order cytotec online[/url]

  59. Annahig says:

    [url=]stromectol medication[/url]

  60. Link exchange is nothing else however it is only placing the other
    person’s web site link on your page at proper place and other person will also do similar in favor of you.

  61. Carlhig says:

    [url=]sildenafil pharmacy[/url]

  62. Kimhig says:

    [url=]ivermectin 50[/url]

  63. I would like to thank you for the efforts you’ve put
    in writing this site. I really hope to check
    out the same high-grade content from you later on as
    well. In fact, your creative writing abilities has inspired
    me to get my own blog now 😉

  64. Wow, this post is nice, my younger sister is analyzing these kinds of things, so I
    am going to inform her.

  65. Nickhig says:

    [url=]viagra soft tabs canada[/url]

  66. Markhig says:

    [url=]price of real viagra[/url]

  67. Evahig says:

    [url=]generic viagra on line[/url]

  68. Samhig says:

    [url=]doxycycline 100mg pills[/url]

  69. Yonhig says:

    [url=]cheap sildenafil online[/url] [url=]cost of cialis daily use[/url] [url=]accutane singapore cost[/url]

  70. Janehig says:

    [url=]where to buy female viagra in india[/url]

  71. Jackhig says:

    [url=]rx pharmacy no prescription[/url]

  72. Boohig says:

    [url=]canadian pharmacy sildenafil[/url] [url=]rx sildenafil tablets[/url] [url=]price of prednisone[/url]

  73. Ivyhig says:

    [url=]suprax 100[/url]

  74. Evahig says:

    [url=]cialis 5 mg daily use cost[/url]

  75. Kiahig says:

    [url=]buy modafinil uk fast delivery[/url]

  76. Judyhig says:

    [url=]purchase stromectol[/url]

  77. Does your website have a contact page? I’m having trouble locating it but,
    I’d like to shoot you an e-mail. I’ve got some recommendations for your blog you might
    be interested in hearing. Either way, great blog and I look forward to seeing it improve over time.

  78. Wimhig says:

    [url=]viagra price comparison canada[/url] [url=]35 viagra[/url] [url=]stromectol online[/url] [url=]cheap sildenafil[/url] [url=]sildenafil 220[/url] [url=]cialis daily price[/url]

  79. Zakhig says:

    [url=]sildenafil cost compare 100 mg[/url] [url=]cost of 10mg tadalafil pills[/url] [url=]cialis 20 price[/url] [url=]viagra 100mg mexico[/url] [url=]how much is ivermectin[/url] [url=]viagra for sale online[/url]

  80. Joehig says:

    [url=]cephalexin 500mg capsules[/url]

  81. Paulhig says:

    [url=]xenical australia cost[/url]

  82. Judyhig says:

    [url=]cialis brand for sale[/url]

  83. Wimhig says:

    [url=]augmentin rx[/url] [url=]buy cialis online safely[/url] [url=]viagra tablet[/url] [url=]where to get tadalafil without a prescription[/url] [url=]viagra generic coupon[/url] [url=]viagra tablets australia[/url] [url=]viagra 1000mg[/url] [url=]viagra 30 mg[/url]

  84. Boohig says:

    [url=]cialis 20 mg buy online uk[/url] [url=]silagra[/url] [url=]viagra discounts[/url] [url=]buying viagra in australia over the counter[/url]

  85. Kiahig says:

    [url=]buy sildenafil online cheap[/url]

  86. Miahig says:

    [url=]viagra over the counter in us[/url]

  87. Jimhig says:

    [url=]canadian pharmacy online tadalafil[/url]

  88. Kiahig says:

    [url=]generic cialis for sale in canada[/url]

  89. Eyehig says:

    [url=]tadalafil 10 mg coupon[/url] [url=]viagra gel australia[/url] [url=]cialis generic australia[/url] [url=]average cost of viagra in canada[/url] [url=]75 mg sildenafil[/url] [url=]tadalafil cost[/url] [url=]cheap azithromycin 500mg[/url] [url=]20 mg cialis daily[/url] [url=]best online pharmacy no prescription[/url] [url=]ivermectin 9mg[/url]

  90. Suehig says:

    [url=]women viagra[/url]

  91. Plaquenil says:

    Acticin How To Buy Website Shop

  92. Ashhig says:

    [url=]online real viagra[/url] [url=]discount pharmacy mexico[/url] [url=]sildenafil 100mg tablets price[/url] [url=]generic viagra 200[/url]

  93. Denhig says:

    [url=]can you buy tadalafil in mexico[/url] [url=]buy cialis cheap canada[/url] [url=]keflex 500 mg capsule[/url] [url=]cheapest uk sildenafil[/url] [url=]tadalafil cost uk[/url]

Leave a Reply

Your email address will not be published. Required fields are marked *